To find the difference b/w two numbers in a column of file?

To find the difference b/w two numbers in a column of file?

Consider a input file with 5 column(0-5):
1 0 937 306 97 3
2 164472 75 17 81 3
3 197154 35268 306 97 3
4 310448 29493 64 38 1
5 310541 29063 64 38 1
6 310684 33707 64 38 1
7 319091 47451 16 41 1
8 319101 49724 16 41 1
9 324746 61578 1 5 1
10 324939 54611 1 5 1
for the second column i,e column1(0,164472,197154-----------) need to find
the difference b/w numbers so that the column1 should be
(0,164472-0,197154-164472,____) so (0,164472,32682..............).
And the output file must change only the column1 values all other values
must remain the same as input file:
1 0 937 306 97 3
2 164472 75 17 81 3
3 32682 35268 306 97 3
4 113294 29493 64 38 1
5 93 29063 64 38 1
6 143 33707 64 38 1
7 8407 47451 16 41 1
8 10 49724 16 41 1
9 5645 61578 1 5 1
10 193 54611 1 5 1
if anyone could suggest a python code to do this it would be helpfull........